Structural defects
95% of structural variants are caused by single amino acid replacement .This amino acid replacement or substitution changes the quality or characrtistics of haemoglobin. For example HbS, C, E, D, G, O all contain substitution of a different amino acid into the normal amino acid sequence of beta globin chain.
Sickle cell disease
Hemoglobin S
HbS substitution of Glutamic Acid at position 6 of the beta globin gene leading to the production of a defective form of hemoglobin S. HbS has a tendency to polymerize and deform the red blood cells into characteristic sickle cell.
Prevalence: Effects million throughout the world. Common in sub-Saharan Africa, Cuba, South America, Central America, Saudi Arabia, India, Mediterranean.
- Homozygous sickle cell: HbSS
- Heterozygous sickle cell: HbSA
- Compound Heterozygous: HbSE, HbSE, HbD Punjab, HbS O Arab, HbS/HPFH, HbS/Beta Thal, HbS/alpha Thal.
Sickle Cell Disease Haplotypes
- Senegal
- Benin
- Bantu
- Asian
Pathophysiology
Deoxygenation of HbS leads to the conformational changes triggers the formation of large polymers that distorts red blood cells into a sickle shape and decreases the elasticity.
- complex chronic inflammatory condition.
- State of chronic activation of coagulation system.
- Red cell membrane abnormalities.
- Nitric oxide depletion
- Increase whole blood viscosity
Clinical Manifestations Sickle Cell Disease
- Anemia
- Crisis
- complications
Acute complications
- Aplastic crisis
- Acute chest syndrome
- Acute splenic sequestration
- Acute painful crisis
- Priapism
- Stroke
- Recurrent Vasoclusive crisis
- Papillary necrosis
- Sepsis
Chronic complications
- Anemia
- Jaundice
- Splenomegaly
- Cardiomegaly
- Cholithisais
- Delayed growth
- Pulmonary hypertension
- Leg ulcers
- Retinopathy
- Avascular necrosis
- Transfusion Hemosiderosis
Sickle Cell Disease Types of Crisies
- Hemolytic crisis
- Aplastic crisis
- Sequestration crisis
- Vasoclusive crises
Sickle Cell Disease Diagnostic Tools & Treatment
Diagnostic Tools
- Peripheral blood finding.
- Sickling test
- Haemoglobin electrophoresis.
- ESR .
- Unconjugated bilirubin.
- LDH & haptoglobin.
- Newly born screening.
- Prenatal diagnosis.
Sickle Cell Disease Treatment
- Daily preventive measures.
- Routine health care .
- Infections.
- Transfusion therapy.
- Pain management.
- New therapeutic modalities.
- Hydroxyurea
- Bone marrow transplantation.
- Psychosocial issues.
- Gene therapy.
Happy 73rd Independence Day of Pakistan
on behalf of Dr. Asim Qidwai (Founder & CEO, AMTF)
#PakistanZindabad #AMTF
Engro Foundation invited Dr. Asim Qidwai, Founder and CEO of AMTF (Afzaal Memorial Thalassemia Foundation) in their session #heroesamongus in honor of Pakistan's #IndependenceDay celebration. They wanted to know and honor his journey by learning about the initiatives he took and the seventeen year's worth of dedicated effort behind AMTF.
Let’s celebrate the heroes among us. One way of doing that is by listening to their stories and supporting their cause. Join us live on Engro Foundation's Instagram for a live session with Dr. Asim and find out their story and initiatives taken.
Date: 6th August, Thursday
Time: 4pm - 5pm
#IATC #HeroesAmongUs #14thAugust #PakIndependenceDay #IndependenceDay #Engro #EngroFoundation
افضال میموریل تھیلیسیمیا فاونڈیشن میں بچوں کی زندگی بچانے کے لیے ہر گروپ کے خون کی اشد ضرورت ہے
Health is a blessing we all pray for and a very few get showered by. This Eid, let's remember those who are fighting for their lives every day with a mere hope that they too will be blessed by it one day.
Stay safe. Stay healthy. Eid Mubarak!
Fidya, Fitra, Zakat, Sadqaat & Blood Donation. Step forward and make your effort count. In these troubling times don't forget who are at war for their lives, because together we can!
For more information, call +92-321-3784538 or visit our website: afzaalfoundation.org
اپنی زکوۃ،خیرات اور عطیات سے گھر بیٹھے تھیلیسیمیاکےبچوں کی زندگی بچانےمیں افضال میموریل تھیلیسیمیا فاونڈیشن کا ساتھ دیں
bit.ly/3cfejdS
AMTF Donation Pick up Form (Karachi Only)
bit.ly
You are requested to provide information for call back آپ سے گزارش ہے کہ کال بیک کے لئے معلومات فراہم کریںThis Ramadan, donate Zakat, donate smiles.With every donation you make for the children at AMTF, you're becoming a source of light for all those who've lost hope in these dark times.
Play your part, play it right!
For more information, call +92-321-3784538 or visit our website: afzaalfoundation.org
Be it a small amount or a large one, this Ramadan, make every donation count at AMTF. Every Zakat you donate through Meezan Bank and AlBaraka Bank has the power to change a life and spread happiness!
Become the source of light for others.
For more information, call +92-321-3784538 or visit our website: afzaalfoundation.org/donation/
18 Glorious years of Compassion and Commitments.
Dedication and a bond of care we share with our patients have made us come this far.
Donate Zakat to AMTF thalassemia patients.
Be charitable, Be sympathetic.
Call +92-321-3784538 for more information or visit our website: afzaalfoundation.org/donation/
One donation, thrice the blessings... For every blood donation that you make, our patients get platelets, FFP and red blood.
Keep donating, keep saving lives!
Call +92-321-3784538 for more information or visit our website: afzaalfoundation.org/donation/
Want to make a difference? Know all about AMTF before you decide to give your zakat, to rule out any confusion. Every donation you give, is a step towards better cure. Donate to save, because together we can!
Call +92-321-3784538 for more information or visit our website: afzaalfoundation.org/donation/
Appeal from Dr Asim Qidwai
“My patients are my guest”
AMTF best-structured program completed phase 1 for Haemoglobinopathies. My request/demand from Pakistan and overseas Pakistani’s on the basis of AMTF 17 years dedicated services to support AMTF.
May Allah give us strength! Ameen
Here we share a glimpse of AMTF quality services.
This holy month of Ramadan, let’s pray for forgiveness, blessings and tolerance that become a source of light for us in these dark times. Wishing you a peaceful and serene Ramadan.
Dr. Asim Qidwai
Founder & CEO, AMTF
Dr Qidwai Appeals in Ramadan for Zakat & Donations in this COVID CRISIS.
Ehaas Karo...Kuch Khaas Karo!
Please Donate online. (Zakat and Donations)
afzaalfoundation.org/donation/
While isolated at our homes due to COVID-19, we have a constant fear of food and water becoming scarce.
Donate for the survival of those whose lives depend on your blood donations. Donate to save, because together we can!
For more information, please visit us: afzaalfoundation.org
Thank you SSGC for supporting the cause.Afzaal Memorial Thalassemia Foundation - Official is in need of blood screening kits.
Come forward and DONATE.
For details, please call 0321-3784538 or for online donations, please visit www.afzaalfoundation.org/donation/
No job is too big or small, community service helps all.
Your support is a precious Gift to save them all.
Please support the cause.
Donate online:
afzaalfoundation.org/donation/
Ehsaas Karoo,Kuch khaas Karo
Children with Blood disorders need your support.
Donate online
afzaalfoundation.org/donation/
Dr Asim Qidwai live with Sahir Lodhi on TVONE.
An appeal was made by Dr Farooq Sattar, Dr Asim Qidwai, Dr Farah, and Pharmacist Mr Waqar to the Government for providing free screening kits to all Thalassemia centres in Pakistan for at least four months.
Together we all can make a difference.
Every child with Thalassemia can be saved.
Because everyone can Donate.
Thank you, Pakistan for your continuous Support.
Now we need screening kits to screen our blood.
Donate online.
afzaalfoundation.org/donation/
AMTF APPEALS.
DONATE BLOOD SCREENING KITS.
DONATE ONLINE.
SAVE THALASSEMIA PATIENTS LIVES.
700 PATIENTS = 7 SCREENING KITS.
EACH 100 PATIENTS = 1 SCREENING KIT.
For details: 03213784538.
Donate to AMTF
Support the cause
Ehsaas Karo, Kuch Khaas Karo
Donate online
afzaalfoundation.org/donation/
Shahood Alvi is a Pakistan TV Actor, Director and a Producer visited AMTF Red Bus and Donated Blood. He also appeals to the public to support the AMTF Blood Disorder Program, Pakistan. We are thankful to Shahood Alvi for sparing his time for the cause.
Donate online
www.afzaalfoundation.org
afzaalfoundation.org/donation/
Sadaf Ebrahim (President, Canada Pakistan Association) appeals to the public for blood and online donations for the AMTF Blood Disorder Program, Pakistan.
www.afzaalfoundation.org
afzaalfoundation.org/donation/
Amtf appeals.
Donate online.
Save children suffering from blood disorders.
www.afzaalfoundation.org
afzaalfoundation.org/donation/
Contact # for donation : 03213784538
Dr. Asim Qidwai (Founder & CEO) appeal for Blood Donation for patients of AMTF (RED BUS)
"HUMEY TUM SE PYAR HAI" 🇵🇰🇵🇰🇵🇰
"My Team is my Strength"
#AMTF Red Bus on the move for blood donation drive. AMTF is keeping safety first for our blood bank team and blood donors as well.
We salute the AMTF team and all others who are collecting blood in this critical time and performing their duties. Their efforts will save the lives of many who are in need of blood.
(Dr. Asim Qidwai - Founder & CEO)
Dr. Asim Qidwai (Founder & CEO) appeal for Blood Donation for patients of AMTF
We are facing severe BLOOD shortage due to Corona Virus (COVID19) Outbreak. Please visit us & help Children in need. 03213784538
Please Share on Social Media!
Dr. Asim Qidwai advising Thalassemia patients regarding the coronavirus, COVID-19.
اسلام وعلیکم ورحمتہ اللہ
جیسا کہ آپ لوگ جانتے ہیں کہ افضال میموریل تھیلیسیمیا فاونڈیشن بچوں میں خون کی جان لیوا بیماریوں کے مفت علاج کا مرکز ہے یہاں ہم نہ صرف اپنے رجسٹرڈ بچوں کو 24 گھنٹے مفت علاج کی سہولیات فراہم کرتے ہیں بلکہ کراچی ، اندرون سندھ ،اور بلوچستان سے آئےدیگر بچے بھی ان مفت سہولیات سے فائدہ اٹھا رہے ہیں جسکی وجہ سے اس وقت ادارہ کو فنڈ میں شدید کمی کا سامنا کرنا پڑرہا ہے جسکی وجہ سے ادارہ آپ تمام احباب سے درخواست کرتا ہے کہ ان بچوں کی زندگی بچانے کی جدوجہد میں آپ ماضی کی طرح ہمارا ساتھ دیجیئے اور اس کار خیر میں اپنا حصہ ڈالتے رہیں تاکہ یہ بچے اپنی زندگی جی سکیں
بانی اور سی ای او
افضال میموریل تھیلیسیمیا فاؤنڈیشن
ڈاکٹر عاصم قدوائ
احساس کرو
کچھ خاص کرو
A lifelong dream has reached fruition!
Dr. Asim Qidwai's concept of the Teacher Respect Card for Lab and Diagnostic Services and MOU signing ceremony has been launched at IQRA University, North Karachi Campus, on February 20th, 2020.
Let's Honor Our Teachers!
The #RedBusAMTF a concept by Dr. Asim Qidwai arrives at #GulAhmed Textile Mills, Karachi for Blood Drive & Advocacy.
February 12 till February 19, 2020
Dr. Asim Qidwai explaining in the recent AMTF documentary about present services offered by Amtf to patients free of cost.
President of Canada Pakistan Association (CPA), Sadaf Ebrahim, CPA Member & Overseas Friends of #AMTF (from Sri Lanka, Malaysia, Canada) visited #AMTF.
Dr Asim Qidwai (Founder & C.E.O) explained about the services that #AMTF provides
February 19, 2020
Dr. Asim Qidwai is working as a special interest in Haemoglobinopathies and childhood cancers. Dr Asim Qidwai is a founder of AMTF Helping Blood disorder program Karachi, Pakistan.
Dr Asim Qidwai did his medical school in 1995 followed by a residency in pediatric medicine, cardiology haematology and oncology. He also completed his masters in Haemoglobinopathies from University College London Hospital. He is the first Pakistan physician who has completed this Master program in Haemoglobinopathies from University College London Hospital.
Dr Qidwai has developed Pakistan first structured program for haemoglobin disorder with a concept of Multidisciplinary team. Dr Qidwai is also a founder member of Children Cancer Hospital and international Bridging foundation.
Dr Asim Qidwai has been actively involved in various research projects and presented several papers in local and international meetings. Dr Asim Qidwai has a special interest in Haemoglobinopathies and his passion is to develop the best centre for children suffering from different kind of blood disorders free of cost.
Under his leadership, Amtf project is the winner of " I am the change" 2016, "SATHA" (South Asia Triple Helix Award) 2018, "IFA Cambridge Child welfare" 2019.
#DrAsimQidwai
#CSRAward2020 #TheProfessionalsNetwork
www.theprofessionalsnetwork.pk
"Golden Lady of the Year 2019" Award
Presented to: Dr. Dur e Naz Jamal (Director - SBTA)
Presented by : Dr. Asim Qidwai (Founder & CEO - AMTF)
An initiative taken by Dr. Asim Qidwai and #AMTF to acknowledge the remarkable work and astonishing efforts of individuals in Health Sector of Pakistan
January 24, 2020
The #RedBusAMTF a concept by Dr. Asim Qidwai arrives at #PIA Township, Karachi for Blood Drive & Advocacy.
January 18, 2020
The #RedBusAMTF a concept by Dr. Asim Qidwai arrives at Lakhani House, Adamjee Nagar, Karachi for Blood Drive & Advocacy.
January 12, 2020
The #RedBusAMTF a concept by Dr. Asim Qidwai arrives at #PIA Head Office, Karachi for Blood Drive & Advocacy
December 12, 2019
#RedBus at Happy Palace School (Isfahani Campus)
for #AMTF Blood Donation Drive
December 5, 2019
Syed Zafar Abbas Jafri of JDC Foundation Pakistan visited #AMTF
December 4, 2019
#RedBus at Thailand Consulate, Karachi
for #AMTF Blood Donation Drive
December 4, 2019
Free Medical Camp in association of World Diabetes Day at #AMTF
November 30, 2019
#RedBus at Iqra University, Airport Campus, Karachi
for #AMTF Blood Donation Drive
November 28, 2019
#AMTF Blood Donation Drive and Free BMD & Sugar Test at Naval Housing Society, Zamzama Karachi.
November 23, 2019
#AMTF Blood Donation Drive at Iqra University, Nazimabad Campus, Karachi
November 16, 2019
#RedBus at Indonesian Consulate, Karachi
for #AMTF Blood Donation Drive
November 16, 2019
#AMTF Blood Donation Drive at PAF KIET North Nazimabad Campus, Karachi
November 9, 2019
World Diabetes Day at #AMTF
Saturday, 30th November, 2019
Free Laboratory Tests:
-Blood Sugar
-Blood Cholesterol
-Blood Uric Acid
-Blood Pressure
-Body Weight
-Body Mass Index (BMI)
-Bone Mineral Density (BMD)
-Diabetic Peripheral Neuropathic Pain (DPNP)
-Ultrasound (Whole Abdomen Only)
Free Clinic Checkup:
-Dr. Waqar Sagheer (Consultant Diabetologist, Chest Specialist -AKUH) - 10:30 am - 1:30 pm
-Dr. Zia ul Hassan (Physician & Cardiologist, Dip Card.) 10:00 am - 12:00 pm
- Dr. Hussain Hadi (Pediatrician) 3:30 pm - 5:00 pm
- Dr. Kashif Ahsan (Physician, Endocriologist - AKUH) 2:00 pm - 5:00 pm
#AMTF Blood Donation Drive at #MobiTising, Shahra e Faisal, Karachi
November 7, 2019
#AMTF Blood Donation Drive at Bahria University #BUKC, Karachi
October 31, 2019
#AMTF Blood Donation Drive at Kokan Ground, Bahadurabad, Karachi
October 27, 2019
#AMTF Blood Donation Drive & Thalassemia Awareness Session at #PICT (Pakistan International Container Terminal), Kemari, Karachi
October 14, 2019
#AMTF Blood Donation Drive at Saima Liberty Tower, North Nazimabad, Karachi
October 13, 2019
#AMTF Blood Donation Drive & Thalassemia Awareness Session at #SGS, Pakistan (Pvt) Ltd, Karachi
October 10, 2019
#AMTF Blood Donation Drive at PAF-KIET, Shahra e Faisal, Karachi
October 2nd & 3rd, 2019
URGENT:
Thalassemia kay mareez bachoon ki zindagi bachane kay liye khoon kay atiyat ki shadeed zaroorat hai.
Fori madad kay liye abhi visit karein.
AMTF, ST-1C, FB Area, Block-10, Ayesha Manzil, Karachi
Adj: PSO Pump
9:00 am - 10:00 pm
03000546038,02136366452
#AMTF Blood Donation Drive at #TotalPARCO Kemari Terminal, Karachi
August 20, 2019
Mr. Emil Wyss (Ex-Consulate General of Switzerland) visited #AMTF on the Occasion of #IndependenceDay
August 14, 2019
Students of #IBA visited #AMTF for Thalassemia Awareness Session & Blood Donation Drive
July 27, 2019
#AMTF Thalssemia Awareness Session & Blood Donation Drive at Schneider Electric Company
17th & 18th of July, 2019
#AMTF Thalassemia Awareness, Thalassemia Screening & Blood Donation Drive at #OxbridgeSchool, Ahsunabad, Karachi
July 13, 2019
"World Blood Donor Day"
Join hands with AMTF to save the Lives of Thalassemia Patients.
#DonateBlood #BloodDonorDay #14June2019
Geo News Pakistan, fundraising appeal by Dr. Asim Qidwai. Join the cause, support AMTF
Mr. Siraj Kassam Teli (Chairman BMG & Former President KCCI)
&
Mr. Junaid Esmail Makda (President KCCI)
visited #AMTF
May 25, 2019
#Ramzan Blood Donation Drive at #AMTF
- May 18, 2019 (Saturday)
- After Taravih till Sehri
"World Thalassemia Day 2019"
May 8, 2019
Save Next Generation from Thalassemia,
Get Yourself Screen Now.