Beta Thalassemia

Beta Thalassemia


People whose hemoglobin does not produce enough beta protein have beta thalassemia. It is found in people of Mediterranean descent, such as Italians and Greeks, and is also found in the Arabian Peninsula, Iran, Africa, Southeast Asia and southern China and India & Pakistan.

Type of Beta Thalassemia

  • Thalassemia Minor or Thalassemia Trait
  • Thalassemia Intermedia
  • Thalassemia major

Thalassemia Minor or Thalassemia Trait

In this condition, the lack of beta protein is not great enough to cause problems in the normal functioning of the hemoglobin. A person with this condition simply carries the genetic trait for thalassemia and will usually experience no health problems other than a possible mild anemia.

Thalassemia Intermedia

Thalassemia Intermedia has an extra ordinary wide clinical spectrum which includes mild and sever end. In case of mild end the person is asymptomatic until adult life ,while in case of sever end there is an early presentation between 2-6 years and that is why there is a borderline between thalassemia intermedia and the most severe form, thalassemia major, which can be confusing. Three main factors are responsible for clinical sequel of Thalassemia intermedia.

  • Ineffective erythropoiesis
  • Chronic Anemia
  • Iron Overload

Thalassemia Major or Cooley ’s anemia

This is the most severe form of beta thalassemia in which the complete lack of beta protein in the hemoglobin causes a life-threatening anemia that requires regular blood transfusions and extensive ongoing medical care. These extensive, lifelong blood transfusions lead to iron-overload which must be treated with chelation therapy to prevent early death from organ failure.

Clinical Diagnosis

Beta Thalassemia Major

  • Age 4 – 6 months or a child younger than 2 years of age .
  • Anemia
  • Hepatosplenomegaly
  • Jaundice
  • Thalassaemia Facies
  • Growth failure & retardation

Beta Thalassemia Intermedia

  • Milder Anemia
  • Extensive Thalassemia Facies
  • Hepatosplenomegaly

Alpha Thalassemia Treatment

  • Preventive & supportive
  • Folic acid supplements if evidence of hemolysis.
  • Avoid oxidative compounds medications.
  • Avoid iron therapy unless iron deficiency documented and periodic monitoring of iron overload.
  • Prompt treatment of infections.
  • Splenomegaly: If marked splenomegaly consider pre splenectomy work up & splenectomy.
  • Special attention for pregnant women with HbH.
  • Risk of fetal neural tube defect. Folic acid supplements during periconceptual period and beyond.
  • Iron supplements if iron deficient
how can we help you?

Contact us at the AMTF office or submit a Inquiry form online.

Free Thalassemia Screening, Free CBC, Free Sugar Testing, Free BP Checkup at Clinical Advisors, Gulshan e Iqbal, Karachi
Sunday 17, 2019
#StopThalassemia #TestBeforeMarriage #ThalassemiaFreePakistan #AMTF
... See MoreSee Less

View on Facebook

#AMTF Blood Donation Drive at P&G Pakistan, Hub Plant
February 14, 2019
#DonateBlood #SaveLife #StopThalassemia #TestBeforeMarriage
... See MoreSee Less

View on Facebook

Free Thalassemia Screening Camp at Chinniot Hospital, Korangi Karachi
Saturday 9, 2019
#StopThalassemia #TestBeforeMarriage #ThalassemiaFreePakistan #AMTF
... See MoreSee Less

View on Facebook

#AMTF representation at
8th Annual Corporate Social Responsibility Summit 2019 #CSR
January 31, 2019
... See MoreSee Less

View on Facebook

Commissioner Karachi visited #AMTF
January 26, 2019
... See MoreSee Less

View on Facebook

#AMTF's First Blood Donation Camp in Blood Donation & Advocacy Bus at Lakhani House
January 20, 2019

#DonateBlood #SaveLife #StopThalassemia #TestBeforeMarriage
... See MoreSee Less

View on Facebook

Ms. Anna Ruffino, Consul General of Italy in Karachi visited #AMTF
January 22, 2019
... See MoreSee Less

View on Facebook

Your blood donation can save a life. Donate blood today and give someone lifeline.
Contact us today: 0213-6366452 | 0321-3784538
Log on to
#AMTF #helpingblooddisorders #blooddonation #savelife #helpothers #thalassemia #sharehappiness
... See MoreSee Less

View on Facebook

for donations click here